Endocrine Abstracts

Objective: The aim of this study was to investigate whether SUR2A (sulfonylurea receptor type 2A, ABCC9) MEF2a (myocyte enhancer factor-2a) and HIF1a (Hypoxia-inducible factor-1) can influence glucose uptake in oxidative muscle soleus by regulating GLUT4 expression.Methods: Insulin resistance was induced in male Wistar rats by inducing obesity with monosodium glutamate (MSG). At the age 3 months, half control and MSG-treated animals started receiving 0.1...

Introduction: GLUT4 protein is the most important isoform of glucose transporters in skeletal muscle. Reduction in its content and/or translocation is related to insulin resistance and type 2 diabetes mellitus. In skeletal muscle cells there is also an ATP-sensitive potassium (KATP) channel with two subunits, sulfonylurea receptor type 2A, ABCC9 (SUR2A) and KIR6.2 (KCNJ11). In pancreatic B cells, this channel triggers insulin secretion in response to the rise in glucose levels...

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

Introduction: In our country somatropin treatment is supported by the National Health Service. A National Committee (CNNHC) rules and analysis the submission papers of patients with: isolated/multiple somatotropin deficiency (STD), short stature in: renal chronic disease (DRC), small for gestational age (SGA), Turner syndrome (TS) and Prader Willi syndrome (PWS). In adults only isolated somatropin deficiency diagnosed in childhood.Aims: To analyze the ch...